The Muscular System
Skeletal, Cardiac, and Smooth Muscle-- Let's Move!















Like all cells, the muscle fiber/cell is quite complex. It has several unique anatomical and physiological specializations that optimizes it for its critical functions





The plasma membrane of the muscle cell is called the sarcolemma.


The cytoplasm of the cell is called sarcoplasm. The sarcoplasm contains several chemical that optimizes the cell for the creation of metabolic energy.


The cell is jam packed with protein containing rod like organelles known as myofibrils.


The myofibrils are made up of organized proteins that interact with one another to cause muscle contraction. These proteins are collectively known as myofilaments and are responsible for the characteristic striated appearance of skeletal muscle.


Each myofibril is loosely surrounded by a series of tubules known as the sarcoplasmic reticulum. This structure is responsible for the cellular transport and storage of chemical, intracellular calcium in particular.


At regular intervals the sarcoplasmic reticulum thickens and changes direction by 90 degreees to form the terminal cisternae.


Transverse tubules are situated in between two terminal cisternae. The orientation of the T-tubules and terminal cisternae is called a Triad. The transverse tubules open to the external extracellular environment via an opening of the sarcolemma, known as the T-tubules openings


Given that muscle contraction is a high metabolic activity the cell is packed with multiple mitochondria. The mitochondrion is an organelle that is the site of cellular respiration that produces the chemical ATP that is used to generate metabolic energy.


The muscle cell has multiple nuclei. Muscle cells are some of the longest cells in the body.







Microscopic Anatomy of the Myofibril





Myofibrils are composed of bundles of proteins known as myofilaments. These fibers include actin and myosin and other structural proteins.





The myofilaments are responsible for the striated appearance of skeletal muscles


The myofilaments are named as thick filaments and thin filaments


The thick filaments are made up of bundles protein molecules known as myosin


The thin filaments are made up of protein molecules known as actin


These filaments are attached to by other proteins to vertical protein referred to as a Z disc


The distance between Z discs is called a sarcomere


The average distance between sarcomeres is 2.2 micrometers


The sarcomere is the basic unit of contraction


The physiology of muscle contraction takes place within sarcomeres


Muscle contraction occurs as a result of direct chemical interaction of the proteins actin and myosin