Pain may precipitate a variety of physiological responses. These responses can be categorized as sympathetic and local.
Local responses are all interrelated. They include:
Muscle Spasm
Edema
Endogenous Chemical Release
Muscle spasm is the reflexive tendency to attempt to immobilize the injured part, perhaps in an attempt to prevent further injury. Muscle spasm requires a relatively high level of metabolic activity and causes compression of blood vessels. The compromised circulation could become inadequate to meet the higher metabolic needs leading to ischemia and a new source of pain.
Edema (swelling) may result due to a disruption of capillaries and lymphatics by trauma or secondary compression from muscle spasm. Edema may complicate the problems of waste removal and nutrient supply and may cause more pain.
Endogenous Chemical Release The release of potassium, serotonin, bradykinin, histamine, prostaglandins, leukotrines, as a consequence of trauma can directly activate nociceptors or may act alone or in combination to sensitize nociceptors to other agents.
Pain-Spasm-Pain Cycle
As the responses interact a cycle of pain may arise. The pain may cause spasm. The spasm may disrupt the local vascular system and impair the delivery of nutrients and waste removal precipitating pain, which in turn may lead to more spasm and so on....
Physical therapy procedures may be directed at breaking the cycle an any point to mitigate the pain.